BAL directly models the posterior distribution of the global optimum (or native structures for protein docking) with active sampling and posterior estimation iteratively feeding each other. Results: We introduce a novel algorithm, Bayesian Active Learning (BAL), for optimization and UQ of such black-box functions and flexible protein docking. Despite progress in this field, there is no docking method available for rigorous uncertainty quantification (UQ) of its solution quality (e.g. Motivation: Ab initio protein docking represents a major challenge for optimizing a noisy and costly "black box"-like function in a high-dimensional space.
This study represents the first UQ solution for protein docking, with rigorous theoretical frameworks and comprehensive empirical assessments. BAL's estimated probability of a prediction being near-native achieves binary classification AUROC at 0.93 and AUPRC over 0.60 (compared to 0.50 and 0.14, respectively, by chance), which also improves ranking predictions. Quality assessment empowered with UQ leads to tight quality intervals with half range around 25% of actual interface RMSD and confidence level at 85%. Over a protein-docking benchmark set and a CAPRI set including homology docking, we establish that BAL significantly improves against starting points from rigid docking and refinements by particle swarm optimization, providing a top-3 near-native prediction for one third targets. Furthermore, it uses complex normal modes to span a homogeneous, Euclidean conformation space suitable for high-dimensional optimization and constructs funnel-like energy models for quality estimation of encounter complexes. native structures) with active sampling and posterior estimation iteratively feeding each other. BAL directly models the posterior distribution of the global optimum (i.e. To fill the gap, we introduce a novel algorithm, Bayesian Active Learning (BAL), for optimization and UQ of such black-box functions with applications to flexible protein docking. Despite progress in this field, there is a lack of rigorous uncertainty quantification (UQ). It is a somewhat similar technique but can be more performance-friendly.Ab initio protein docking represents a major challenge for optimizing a noisy and costly "black box"-like function in a high-dimensional space. Does not actually use ray tracing, but rather Path Tracing or PTGI. Otherwise, there are multiple shaderpacks that is not as intensive on your PC, you can search them up in Google for "lagless" shaderpacks!Ī: Currently (June 27, 2019), SEUS, the most prolific shaderpack and the most advanced ever yet.
Which means, it only affects the client and does not modify any other crucial data that can affect playability in ServersĪ: Short answer, get a stronger PC. Try and search for them individually)Ī: No, there is none, although only one Shaderpack can be open at any given time.Ī: Shaders is a singleplayer mod. (for some reason, is not working, specifically, any shaderpack link doesn't work. There are many Shaderpacks like SEUS, KUDA Shaders, Sildur's Vibrant Shaders, and more! You can switch it on the Version tab below your profile at the bottom left corner of the Minecraft LauncherĪ: Search them individually. Q: I can't find the Shaders button on the Options menu!Ī: make sure you have installed Optifine and are using the version modified by Optifine.
Go to your Options in Minecraft, Video Settings, Shaders and turn it on, go into your world and enjoy!Ī: just go to "%appdata%/.minecraft" in Windows
minecraft on your appdata (on Windows just put %appdata% on the file directory!) then put all your shaderpacks in there!Īfter you install Optifine, your Minecraft Launcher should auto-choose the correct version of the game it should run which is the Optifine-modified version, if not select it from the Minecraft Version list on the bottom left of the launcher and then Run the game!
zip formats, make a "shaderpacks" folder on.
Shader mods allow you to use your Shaders, what makes each and every shaders from different makers are Shaderpacksįrom Sonic Ether's Unbelievable Shaders, KUDA Shaders, Continuum Shaders, all the good stuff!Ĭhoose one (or two or even lots!) download it! jar folders, get Java Runtime Environment ) jar, run the program and it will install for you (if you can't open.